6.2L V8 connecting-rod / crankshaft failure — recall 25V274
CoveredThe defining 2021 issue if the truck has the 6.2L — and the Sierra Denali, which skews to that engine, is disproportionately affected. GM recalled about 597,571 vehicles (2021–2024 Sierra, Silverado, Tahoe, Yukon, Escalade) for connecting-rod and crankshaft defects that put debris in the oil and can cause sudden engine failure — 'no warning, just died' — with NHTSA expanding its probe twice. GM estimates roughly a 3% defect rate; the remedy inspects and repairs or replaces the engine free and moves to 0W-40 oil. A used 6.2L that's been through the recall is a known quantity; one that hasn't is an open question. Confirm completion by VIN.
Sources: NHTSA complaint database, 2021 Sierra 1500 · NHTSA recall database and manufacturer communications (recall 25V274; transmission-valve coverage; eBoost CSP)
5.3L Dynamic Fuel Management (DFM) lifter failure
$3,000–$10,000If it's the 5.3L, the lifter issue rides on. DFM can deactivate any of all eight cylinders, and mechanics say its lifters fail more often and earlier than the older AFM — a tick, misfire, power loss, and a $3,000–$10,000 repair with no recall, only a class action and reactive warranty repairs. A DFM disabler (~$150) is cheap prevention and a cold-start tick is the walk-away sign. The 6.2L's risk is largely covered by its recall while the 5.3L's lifter risk is not — factor that into which one you buy.
Sources: NHTSA complaint database, 2021 Sierra 1500 · Independent mechanic transcripts (T1XX Silverado/Sierra; AFM/DFM lifter deep-dives)
8-speed transmission — costliest failure is covered
CoveredThe 8-speed can still shudder and shift harshly, but the expensive control-valve failure is covered on this year by GM's 15-year/150,000-mile Special Coverage (from the in-service date, regardless of ownership) — a new valve body free, with reimbursement for prior repairs. The 10-speed on other trims is the stronger unit. Test-drive for shudder and confirm the coverage window. There is a second 2021 transmission program worth checking alongside it: a Customer Satisfaction Program for trucks with the 8-speed (GM's option code MQE) that “may have a broken reaction carrier in the transmission,” where the remedy is to replace the transmission. It is the first federal document tying a 2021 truck's 8-speed to a full replacement rather than a valve body or a fluid change — VIN-check it as well as the control-valve coverage.
Sources: NHTSA recall database and manufacturer communications (recall 25V274; transmission-valve coverage; eBoost CSP) · Independent mechanic transcripts (T1XX Silverado/Sierra; AFM/DFM lifter deep-dives)