5.3L Dynamic Fuel Management (DFM) lifter failuremajor
If it's the 5.3L, the lifter issue rides on. DFM can deactivate any of all eight cylinders, and mechanics say its lifters fail more often and earlier than the older AFM — a tick, misfire, power loss, and a $3,000–$10,000 repair with no recall, only a class action and reactive warranty repairs. A DFM disabler (~$150) is cheap prevention and a cold-start tick is the walk-away sign. The 6.2L's risk is largely covered by its recall while the 5.3L's lifter risk is not — factor that into which one you buy.
Sources: NHTSA complaint database, 2021 Sierra 1500 · Independent mechanic transcripts (T1XX Silverado/Sierra; AFM/DFM lifter deep-dives)
~$150
DFM disabler module (preventive)
$3,000–$10,000
Lifter/valvetrain repair after failure